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Depends on the niche of the site, make up of the visitors, what advertising you're doing, the rates you charge if you;re doing paid advertising vs adsense, how much advertising you're doing, where in the sky the moon is, what you ate for breakfast, what browsers your visitors are using, what's on television that night, who's on first....
Gotta admit that I'm surprised you asked such a open ended question like that without giving any details.
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