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You're basically talking about cold calling. Spam is random and is based on bulk messaging. You send out 100 million messages and get a .0001% response and still make a profit but your message has to be short and sweet. Basically setup business, make your few thousand of dollars worth of spam business and then close up shop.
When you cold call a customer you're targeting a group of people that may be interested in your services. People that registered a car at the DMV recently would be interested in car insurance, oil changes, car repair, etc. People that just set up a business would be interested in book keepers, accountants and advertising agencies.
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