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Yeah you can. It's still related, it's not like you are exchanging links with celebrity and movie review site, it's still a related niche to yours.
You also need to think about your target audience..let's say you have a site on high blood pressure, it makes sense to go out and exchange links with diabetes sites then because people who have diabetes are likely to have High blood pressure and so on.
If it works for your target customers and also brings back links, I wouldn't worry about angering the google gods.
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