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I would suggest getting hijack this and posting a log. That program also has a 'delete on startup' option for those particular files that just wont let you take them out if they've been registered and are active.
Also, post the file names of the particular files you're trying to delete. Or do research on them to make sure they are the problem. There's usually a malicious software removal app out there for most of the nastier stuff that a standard av wont get rid of.
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