i have used this one before, Group Mail Free, --->
http://www.infacta.com/gmdifferences.asp works nice and it is free.
You can send to 100 adresses at a time, so you just have to devide your database into, textfiles, files with 100 adresse, or you get the pro ver. and you can use whatever database you have.
Quote:
Importing data from existing applications or databases couldn't be easier. Group Mail can import practically any file type, text, CSV, binary, databases, and email address books. At present any database that supports ODBC or OLEDB (SQL Server, Oracle, MySQL, Access, FoxPro, Excel, etc.) can be imported directly into Group Mail using the free Database Importer plug-in (available to Plus users only). Currently supported (no export to CSV required!!) address book formats including distribution lists are: Eudora, Outlook Express, Outlook, Netscape, Opera 6.0, AOL 7.0, Lotus Notes, Exchange, PINE, GroupWise and other formats are being added continuously. All data imported is checked for duplicates and all email addresses are validated using strict industry standards for formatting.
Messages can be created in Text or HTML (or transformed from XML) and can include images, formatting (font styles etc.) and links.
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