Depends
That honestly depends on the market you are in, the keywords you are bidding on, the quality of your site, etc. There is no yes or no answer for this. I would recommend starting some small test campaigns, and seeing how they do. Give them very limited budgets, see what your conversion rate is over a month, revise your ads, and just track. If you are making money on your sales, it can be a good way to get an immediate boost in traffic and sales. On the other hand if it costs you $10 to sell a $4 item, it doesn't really make sense to do so.
I would start off with MSN before I did google, from other webmasters, and looking at my own sales they convert at a higher rate, and it is great to be able to work in Excel them import campaigns when reworked, a true time saver.
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