Welcome to the community. I hope you enjoy your stay here
hmm, that's tricky. Do you have a layout in mind? One thing I can advise you to do is stay away from using really bright colors. You can use them in small items on a site, but never as a main background color etc. Stick with colors that are easy on the eye, meaning, you can spend up to about 20 minutes at a time reading on the site without your eyes hurting or straining.
You can also use colors that are complimentary to a logo etc. But I can't offer any solid advice if I can't see a template or the actual site online. Is is a new site? Or are you upgrading an existing site?