You can do this very easily if you create the page in adobe Imageready.
If youre familiar with photoshop layers its pretty easy. You create your image, make separate layers representing the rollover states, break the page into slices, then use the rollovers palette to create the mouseovers.
The rollovers are "slice" dependent, and you can change any slice on the page with just one mouseover. So if my site has 3 slices, I can make it so if I mouseover slice #1, slices 2-3 will change. If you arent sure how to do any of this, go to the adobe.com support page.